一、导师基本情况

姓名：范念斯

职称：副教授

办公电话：13601190374

邮箱：nsfan@hznu.edu.cn

二、研究领域

废水生物处理技术的开发与应用、新兴污染物的归趋与消减、环境微生物的种间互作机制

三、主讲课程

《环境工程微生物》、《环境工程微生物实验》       

四、教育和工作经历

l    2018年08月——今，杭州师范大学，副教授  

l    2012年09月——2018年06月，中国科学院生态环境研究中心，环境工程，博士（硕博连读）

l    2012.09-2014.06 中科院大学中丹学院-哥本哈根大学，环境科学，硕士（双学位）

五、学术简介（控制在300-400字）

范念斯，博士，硕导。先后在多项国家及省市课题的资助下，系统开展了anammox工艺的应用基础研究，以第一或通讯作者身份在Water Research、Chemical Engineering Journal、Environment International、Journal of Hazardous Materials等国内外学术刊物上发表SCI论文30余篇，Elsevier高被引论文1篇；获授权发明专利5件。为浙江省生态学学会微生物生态学专业委员会委员；长期担任 ES&T、Water Res.等多个SCI刊物的审稿专家。主要学术贡献：1）针对废水中典型污染物对anammox系统的综合影响，进行工艺表现、污泥特性、群落结构、作用机制等方面的研究；2）针对anammox系统中的群体感应现象，探明不同类型信号分子在anammox系统运行及污泥颗粒化过程中的作用；3）针对anammox细菌难富集、难保存等问题，提出一系列经济、有效的anammox颗粒污泥保藏及恢复策略。以上研究推动了anammox工艺处理复合废水的实际应用。

六、主持教学科研项目

1、国家自然科学基金项目，典型兽用抗生素胁迫下厌氧氨氧化系统中的质粒组特征及抗性基因转移机制，2021.01-2023.12，在研

2、浙江省自然科学基金项目，外援信号分子对厌氧氨氧化的影响机制研究，2020.01-2022.12，已结题

3、杭州市科技局项目，厌氧氨氧化工艺处理畜禽养殖废水过程中微生物种群演替规律及响应机制研究，2019.01-2020.12，已结题

七、代表性论著（通讯作者/第一作者，均属JCR Q1）

2023年（截止至9月30日）

[1] Huang D.Q., Wang Q., Yang J.H., Jiang Y., Li Z.Y., Fan N.S.*, Jin R.C.* Deciphering Endogenous and Exogenous Regulations of Anammox Consortia in Responding to Lincomycin by Multiomics: Quorum Sensing and CRISPR System. Water Research, 2023, 239: 120061.

[2] Wu Q., Wang X., Li H.Y., Huang D.Q., Huang B.C., Jin R.C.*, Fan N.S.* Perturbation and mechanism of non-antibiotic drug in regulating resistome and metabolome of anammox consortia: An overlooked and underrated cause of multiresistance. Chemical Engineering Journal 2023, 475: 146325.

[3] Wang X., Wang Q., Wang Z.Z., Ma W.J., Qiu J., Fan N.S.*, Jin R.C.* Biotransformation-mediated detoxification of roxarsone in the anammox process: genetic and mechanistic insights. Chemical Engineering Journal, 2023, 467: 143449.

[4] Huang D.Q., Wang Y., Li Z.Y., Huang B.C., Yang M., Fan N.S.*, Jin R.C.* Metabolomics and molecular simulation reveal the responding mechanism of anammox consortia to perfluorooctanoic acid by regulating metabolic network. Chemical Engineering Journal, 2023, 460: 141712.

[5] Wang Y., Huang D.Q., Yang J.-H., Li G.F., Zhou Y.X., Zhang J.Y., Lu Y., Fan N.S.*, Jin R.C. Polyamide microplastics act as carriers for cephalexin in the anammox process. Chemical Engineering Journal, 2023, 451: 138685.

[6] Yang J.H., Huang D.Q., Geng Y.C., Ling Y.R., Fan N.S.*, Jin R.-C. Role of quorum sensing-based regulation in development of anaerobic ammonium oxidation process. Bioresource Technology, 2023, 367: 128228.

2022年

[1] Ma Y.L., Lu Z.Y., Fu J.J., Fan N.S.*, Jin R.C. Intracellular and Extracellular Protective Mechanisms of the Anammox Consortia Against Exogenous Sulfadimidine. Journal of Hazardous Materials, 2022, 434: 128817.

[2] Ma W.J., Wang X., Zhang J.T., Guo J.Y., Lin Y.X., Yao Y.X., Li G.F., Cheng Y.F., Fan N.S.*, Jin R.C. Adding exogenous protein relieves the toxicity of nanoparticles to anammox granular sludge by adsorption and the formation of eco-coronas. Environmental Science: Nano, 2022, 9(5): 1794-1804.

[3] Huang D.Q., Fu J.J., Li Z.Y., Fan N.S.*, Jin R.C. Inhibition of wastewater pollutants on the anammox process: A review. Science of the Total Environment, 2022, 803: 150009.

[4] Fu J.J., Wang Y., Yang J.H., Huang D.Q., Zhang Q., Huang Y., Chen J.R., Fan N.S.*, Jin R.C. Mitigating the detrimental effects of salt stress on anammox process: A comparison between glycine betaine and mannitol. Science of the total environment, 2022, 851: 158221.

[5] Fu J.J., Huang D.Q., Bai Y.H., Shen X.Z., Huang Y., Ling Y.R., Fan N.S.*, Jin R.C. How anammox process resists the multi-antibiotic stress: Resistance gene accumulation and microbial community evolution. Science of the total environment, 2022, 807: 150784.

[6] Huang D.Q., Fu J.J., Li Z.Y., Huang Y., Fan N.S.*, Jin R.C. Removal of extracellular deoxyribonucleic acid increases the permeability and mass transfer of anammox granular sludge with different sizes. Chemosphere, 2022, 302: 134898.

[7] Huang D.Q., Huang Y., Wu Q., Chen J.R., Li Z.Y., Fan N.S.*, Jin R.C. Anammox sludge preservation: Preservative agents, temperature and substrate. Journal of Environmental Management, 2022, 311: 114860.

2021年

[1] Fan N.S., Fu J.J., Huang D.Q., Ma Y.L., Lu Z.Y., Jin R.C., Zheng P. Resistance genes and extracellular proteins relieve antibiotic stress on the anammox process. Water Research, 2021, 202: 117453.

[2] Ma W.J., Ren Z.Q., Yu L.Q., Wu X.X., Yao Y.X., Zhang J.T., Guo J.Y., Fan N.S.*, Jin R.C. Deciphering the response of anammox process to heavy metal and antibiotic stress: Arsenic enhances the permeability of extracellular polymeric substance and aggravates the inhibition of sulfamethoxazole. Chemical Engineering Journal, 2021, 426: 130815.

[3] Zhang Q., Wu J., Yu Y.Y., He Y.J., Huang Y., Fan N.S.*, Huang B.C., Jin R.C. Microbial and genetic responses of anammox process to the successive exposure of different antibiotics. Chemical Engineering Journal, 2021, 420: 127576.

[4] Zhang Q., Fan N.S.*, Fu J.J., Huang B.C., Jin R.C. Role and application of quorum sensing in anaerobic ammonium oxidation (anammox) process: A review. Critical Reviews in Environmental Science and Technology, 2021, 51(6): 626-648.

[5] Fu J.J., Huang D.Q., Lu Z.Y., Ma Y.L., Xu X.W., Huang B.C., Fan N.S.*, Jin R.C. Comparison of the dynamic responses of different anammox granules to copper nanoparticle stress: Antibiotic exposure history made a difference. Bioresource Technology, 2021, 333: 125186.

[6] Zhang Q., Fu J.J., Wu Q.Y., Chen J.Y., Fan N.S.*, Huang B.C., Jin R.C. Build the expressway for the salt-tolerant anammox process: Acclimation strategy tells the story. Journal of Cleaner Production, 2021, 278: 123921.

[7] Lu Z.Y., Fu J.J., Ma Y.L., Jin R.C., N.-S. Fan* Response of anammox granules to the simultaneous exposure to macrolide and aminoglycoside antibiotics: Linking performance to mechanism. Journal of Environmental Management, 2021, 286: 112267.

2020年

[1] Fan N.S., Bai Y.H., Wu J., Zhang Q., Fu J.J., Zhou W.L., Huang B.C., Jin R.C. A two-stage anammox process for the advanced treatment of high-strength ammonium wastewater: Microbial community and nitrogen transformation. Journal of Cleaner Production, 2020, 261: 121148.

[2] Wu J., Fan N.S.*, Yu Y.Y., He Y.J., Zhao Y.H., Zhang Q., Huang B.C., Jin R.C. Insight into the microbial and genetic responses of anammox granules to spiramycin: Comparison between two different dosing strategies. Journal of Cleaner Production, 2020, 258: 120993.

[3] Zhang Q., Zhang X., Bai Y.H., Xia W.J., Ni S.K., Wu Q.Y., Fan N.S.*, Huang B.C., Jin R.C. Exogenous extracellular polymeric substances as protective agents for the preservation of anammox granules. Science of the Total Environment, 2020, 747: 141464.

[4] Fan N.S., Qi R., Huang B.C., Jin R.C., Yang M. Factors influencing Candidatus Microthrix parvicella growth and specific filamentous bulking control: A review. Chemosphere, 2020, 244: 125371.

[5] Fan N.S., Bai Y.H., Chen Q.Q., Shen Y.Y., Huang B.C., R.-C. Jin. Deciphering the toxic effects of antibiotics on denitrification: Process performance, microbial community and antibiotic resistance genes. Journal of Environmental Management, 2020, 262: 110375.

[6] Fu J.J., Zhang Q., Huang B.C., Fan N.S.*, Jin R.C. A review on anammox process for the treatment of antibiotic-containing wastewater: Linking effects with corresponding mechanisms. Frontiers of Environmental Science & Engineering, 2020, 15(1): 17. (高被引论文)

[7] Lu Z.Y., Ma Y.L., Zhang J.T., Fan N.S.*, Huang B.C., Jin R.C. A critical review of antibiotic removal strategies: Performance and mechanisms. Journal of Water Process Engineering, 2020, 38: 101681.

2019年年及以前

[1] Fan N.S., Zhu X.L., Wu J., Tian Z., Bai Y.H., Huang B.C., Jin R.C. Deciphering the microbial and genetic responses of anammox biogranules to the single and joint stress of zinc and tetracycline. Environment International, 2019, 132: 105097.

[2] Chen Q.Q., Xu L.Z.J., Zhang Z.Z., Sun F.Q., Shi Z.J., Huang B.C., Fan N.S.*, Jin R.C. Insight into the short-and long-term effects of quinoline on anammox granules: Inhibition and acclimatization. Science of the Total Environment, 2019, 651: 1294-1301.

[3] Fan N.S., Wang R.F., Qi R., Gao Y.X., Rossetti S., Tandoi V., Yang M.* Control strategy for filamentous sludge bulking: Bench-scale test and full-scale application. Chemosphere, 2018, 210: 709-716.

[4] Fan N.S., Qi R., Rossetti S., Tandoi V., Gao Y.X., Yang M.* Factors affecting the growth of Microthrix parvicella: Batch tests using bulking sludge as seed sludge. Science of the Total Environment, 2017, 609: 1192-1199.       

八、荣誉与奖励（排名第一）

l  浙江省“高校领军人才培养计划”青年优秀人才，2021年，浙江省教育厅

l  杭州市“高层次人才特殊支持计划”第一层次，2021年，杭州市人社局  

l  杭州师范大学高层次人才第五层次，2021年，杭州师范大学 

l  杭州市高层次人才E类，2018年，杭州市人社局  

l      “苏伊士新创建”优秀论文特等奖  

l 《应用与环境生物学报》2017年度优秀论文奖

九、授权专利及转化（排名第一）

l    [发明专利] 扩散型信号分子DSF在提升功能菌为CandidatusKuenenia的厌氧氨氧化絮状污泥活性中的应用 ZL 202110906893.6

l    [发明专利] 一种添加外源信号分子富集厌氧氨氧化菌的方法 ZL 202110906889.X

l    [发明专利] 牛血清蛋白在缓解纳米氧化镁对厌氧氨氧化颗粒污泥活性抑制中的应用 ZL 202110918422.7

l    [发明专利] 一种厌氧氨氧化菌种的保藏及恢复方法 ZL 201910329646.7

l    [发明专利] 耐受高浓度螺旋霉素的厌氧氨氧化颗粒污泥的培养方法 ZL 201910465251.X

十、作为导师指导竞赛获奖情况

l    2021年，浙江省第十七届“挑战杯”大学生课外学术科技作品竞赛，省二等奖

l    2021年，第四届浙江省大学生环境生态科技创新大赛，省二等奖

l    2020年，第五节全国大学生生命科学创新创业大赛，一等奖2项、三等奖1项

l 指导学生获得“新苗计划”、“国创”、“星光计划”项目多项立项